Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection
نویسندگان
چکیده
منابع مشابه
Insulin resistance, steatosis and hepatitis C virus
Epidemiological studies have shown an increased occurrence of metabolic disorders such as insulin resistance (IR) and steatosis in patients with hepatitis C virus (HCV) infection. IR is believed to represent one of the central clinical features of the "metabolic syndrome" and the major pathogenetic factor for type 2 diabetes mellitus. In patients with chronic HCV hepatitis, IR may have several ...
متن کاملHepatitis C Virus, Insulin Resistance, and Steatosis
Hepatitis C virus (HCV) is one of the main causes of liver disease worldwide. Liver steatosis is a common finding in many hepatic and extrahepatic disorders, the most common being metabolic syndrome (MS). Over time, it has been shown that the frequent coexistence of these two conditions is not coincidental, since many epidemiological, clinical, and experimental studies have indicated HCV to be ...
متن کاملInsulin resistance and steatosis in chronic hepatitis C.
In chronic hepatitis C, insulin resistance (IR) and type 2 diabetes mellitus (DM) are more prevalent than in healthy controls or in chronic hepatitis B patients. HCV infection promotes IR mainly through increased TNF-a and cytokine suppressor (SOCS-3) production. Both events inhibit insulin receptor and IRS-1 (insulin receptor substrate) tyrosine phosphorylation. Hepatic steatosis is also 2.5 f...
متن کاملRace, insulin resistance and hepatic steatosis in chronic hepatitis C.
UNLABELLED Hepatic steatosis is common in chronic hepatitis C and has been linked to concurrent obesity, insulin resistance, diabetes, disease severity, and poor response to therapy. Racial differences in rates of obesity and diabetes may contribute to racial differences in hepatic steatosis and treatment response. The aim of the present study was to compare hepatic steatosis and its associatio...
متن کاملOriginal Articles Steatosis and Chronic Hepatitis C Virus Infection
Objective: To asses the presence of steatosis and other histological changes in patients with chronic hepatitis C. Methods: Liver biopsy samples were reviewed for presence of steatosis, its degree and other histological changes of hepatitis C including necro-inflammatory score, fibrosis grade and these changes were correlated with liver function tests. Results: A total of 109 liver biopsy sampl...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2013
ISSN: 1007-9327
DOI: 10.3748/wjg.v19.i41.7055